Personalized medicine: motivation, challenges, and progress
نویسندگان
چکیده
منابع مشابه
Progress towards personalized medicine.
Personalized medicine is the tailoring of therapies to defined subsets of patients based on their likelihood to respond to therapy or their risk of adverse events. The advent of improved genomic tools has greatly hastened our understanding of the molecular pathology of diseases, enabling us to redefine disease at the molecular level. The development of molecularly targeted therapies, coupled wi...
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MOTIVATION Widespread availability of low-cost, full genome sequencing will introduce new challenges for bioinformatics. RESULTS This review outlines recent developments in sequencing technologies and genome analysis methods for application in personalized medicine. New methods are needed in four areas to realize the potential of personalized medicine: (i) processing large-scale robust genomi...
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How will you respond when a patient asks, "Doctor, what can I do to prevent myself from going blind from glaucoma like mom?". There is optimism that genetic profiling will help target patients to individualized treatments based on validated disease risk alleles, validated pharmacogenetic markers and behavioral modification. Personalized medicine will become a reality through identification of d...
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Background and Aims: Advances of genetic science in genomic techniques have led introducing new diagnostic systems to study the diseases or treatment efficacies. In this science, which named “Personalized Medicine”, human genetic structure is used for evaluation of the diagnosis, treatment, and prevention of disease. Regarding the limited number of studies regarding this issue in Oral & Maxillo...
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GENE HUNTING, SIGNALING NETWORK, AND MOLECULAR MEDICINE In the 20th century, most researchers investigated WNT signaling in cell and developmental biology by using model animals, such as Drosophila, Xenopus, and mouse. However, I was confident that WNT signaling should be investigated for clinical application by using human samples or cell lines. In 1998, I, together with post-doctoral fellows,...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2018
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2018.05.006